Synthesis of lakshminine and antiproliferative testing of related oxoisoaporphines.
J Nat Prod
; 73(11): 1951-3, 2010 Nov 29.
Article
em En
| MEDLINE
| ID: mdl-20961068
ABSTRACT
Lakshminine (6-amino-1-aza-5-methoxy-7H-dibenzo[de,h]quinolin-7-one, 1) is a recent addition to the small family of oxoisoaporphine alkaloids and a member of an even smaller set bearing an amino group at C-6. This rare natural product has now been synthesized in order to have sufficient amounts for biological testing. Lakshminine, its 4-amino isomer (2), their 6- and 4-nitro precursors (8 and 10, respectively), the intermediate 5-methoxy-7H-dibenzo[de,h]quinolin-7-one (6), and the unsubstituted skeleton (11) were tested against normal human fibroblasts and three human solid tumor cell lines. Only compound 10 showed marginal antiproliferative activity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aporfinas
/
Alcaloides
/
Antineoplásicos Fitogênicos
Limite:
Humans
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Chile