Malignant melanoma and Wiedemann-Beckwith syndrome in childhood.
Klin Padiatr
; 222(6): 388-90, 2010 Nov.
Article
em En
| MEDLINE
| ID: mdl-21058226
ABSTRACT
Patients with Wiedemann-Beckwith syndrome (WBS, MIM 130650), a congenital overgrowth syndrome, have a known increased tumor risk especially for embryonic tumors. WBS belongs to the "imprinting" syndromes caused by overexpression of IGF2 and/or loss of CDKN1C on chromosome 11p15.5. A 13-year-old boy with WBS developed a spitzoid malignant melanoma (Clark level V, Breslow index 4.8 mm) on the right cheek. Genetic analyses of the patient's blood showed hypermethylation at the H19 locus on chromosome 11p. The (epi)genetic changes of the WBS locus might have played a role in the pathogenesis of melanoma development.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
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Síndrome de Beckwith-Wiedemann
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Cromossomos Humanos Par 11
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Neoplasias Faciais
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Impressão Genômica
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Metilação de DNA
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Melanoma
Limite:
Adolescent
/
Humans
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Male
Idioma:
En
Revista:
Klin Padiatr
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Alemanha