Augmentation of regulatory B cell activity in experimental allergic encephalomyelitis by glatiramer acetate.
J Neuroimmunol
; 232(1-2): 136-44, 2011 Mar.
Article
em En
| MEDLINE
| ID: mdl-21111489
ABSTRACT
We recently showed that B cells reduce CNS inflammation in mice with experimental allergic encephalomyelitis (EAE). Here, we demonstrate that adoptively transferred CD5/CD19+ B cells protect against EAE severity. Furthermore, we show that glatiramer acetate (GA), a therapeutic for relapsing multiple sclerosis treatment, amplifies this effect. Transfer of GA-conditioned B cells leads to increased production of immunoregulatory cytokines and reduced CNS inflammation, as well as decreased expression of the chemokine receptor, CXCR5, and elevated BDNF expression in the CNS. Thus B cells can protect against EAE, and GA augments this effect in maintaining immune homeostasis and controlling EAE disease progression.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Subpopulações de Linfócitos B
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Encefalomielite Autoimune Experimental
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Imunossupressores
Limite:
Animals
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos