A mathematical framework for examining whether a minimum number of chiasmata is required per metacentric chromosome or chromosome arm in human.
Genomics
; 97(3): 186-92, 2011 Mar.
Article
em En
| MEDLINE
| ID: mdl-21156203
ABSTRACT
We introduce a piecewise linear regression called "hockey stick regression" to model the relationship between genetic and physical lengths of chromosomes in a genome. This piecewise linear regression is an extension of the two-parameter linear regression we proposed earlier [W. Li and J. Freudenberg, Two-parameter characterization of chromosome-scale recombination rate, Genome Res., 19 (2009) 2300-2307]. We use this, as well as the one-piece regression with a fixed y-intercept, to compare the two competing hypotheses concerning the minimum number of required chiasmata for meiosis minimum one chiasma per chromosome (PC) and per chromosome arm (PA). Using statistical model selection and testing, we show that for human genome data, one-piece PC (PC1) is often in a statistical tie with two-piece PA model (PA2). If an upper bound for the segmentation point in two-piece regression is imposed, PC is usually the preferred model. This indicates that a presence of more than one chiasmata is rather caused by the relationship between chromosome size and chiasma formation than by cytogenetic constraints.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Recombinação Genética
/
Troca de Cromátide Irmã
/
Meiose
Limite:
Humans
Idioma:
En
Revista:
Genomics
Assunto da revista:
GENETICA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos