[Preparation and characterization of non-ionic surfactant vesicle of cantharidin].
Zhongguo Zhong Yao Za Zhi
; 35(19): 2546-50, 2010 Oct.
Article
em Zh
| MEDLINE
| ID: mdl-21174762
ABSTRACT
OBJECTIVE:
To study the preparation of cantharidin entrapped non-ionic surfactant vesicle (noisome)and evaluate its quality.METHOD:
The niosome loaded with cantharidin was prepared using injection method by non-ionic surfactants as the carrier. An centrifugation separation method and HPLC analysis method of the cantharidin were established to detect the entrapment efficiency. The optimum preparation technology was established by a orthogonal experiment. The morphology, and particle size were studied to evaluate the preparation.RESULT:
The average size of niosomes were (209. 8 +/- 0.5) nm. The entrapment efficiency of the CTD-NS was (27.5% +/- 2.0%) and Zeta potential was (41.5 +/- 0.65) mV.CONCLUSION:
The preparation of cantharidin noisome by TweenA and SpanB is practicable and successful. These experiments can be the basement of developing targeting drug delivery system.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tensoativos
/
Cantaridina
/
Sistemas de Liberação de Medicamentos
/
Lipossomos
Idioma:
Zh
Revista:
Zhongguo Zhong Yao Za Zhi
Assunto da revista:
FARMACOLOGIA
/
TERAPIAS COMPLEMENTARES
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
China