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Inhibition of beta-secretase in vivo via antibody binding to unique loops (D and F) of BACE1.
Zhou, Lujia; Chávez-Gutiérrez, Lucia; Bockstael, Katrijn; Sannerud, Ragna; Annaert, Wim; May, Patrick C; Karran, Eric; De Strooper, Bart.
Afiliação
  • Zhou L; From the Department of Molecular and Developmental Genetics, VIB and; the Center for Human Genetics, KULeuven, 3000 Leuven, Belgium.
  • Chávez-Gutiérrez L; From the Department of Molecular and Developmental Genetics, VIB and; the Center for Human Genetics, KULeuven, 3000 Leuven, Belgium.
  • Bockstael K; From the Department of Molecular and Developmental Genetics, VIB and; the Center for Human Genetics, KULeuven, 3000 Leuven, Belgium.
  • Sannerud R; From the Department of Molecular and Developmental Genetics, VIB and; the Center for Human Genetics, KULeuven, 3000 Leuven, Belgium.
  • Annaert W; From the Department of Molecular and Developmental Genetics, VIB and; the Center for Human Genetics, KULeuven, 3000 Leuven, Belgium.
  • May PC; the Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, Indiana 46285, and.
  • Karran E; Johnson and Johnson Pharmaceutical Research and Development, 2340 Beerse, Belgium.
  • De Strooper B; From the Department of Molecular and Developmental Genetics, VIB and; the Center for Human Genetics, KULeuven, 3000 Leuven, Belgium,. Electronic address: Bart.DeStrooper@cme.vib-kuleuven.be.
J Biol Chem ; 286(10): 8677-8687, 2011 Mar 11.
Article em En | MEDLINE | ID: mdl-21209097
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Proteases / Encéfalo / Ácido Aspártico Endopeptidases / Secretases da Proteína Precursora do Amiloide / Anticorpos Neutralizantes / Anticorpos Monoclonais Murinos / Neurônios Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Bélgica
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Proteases / Encéfalo / Ácido Aspártico Endopeptidases / Secretases da Proteína Precursora do Amiloide / Anticorpos Neutralizantes / Anticorpos Monoclonais Murinos / Neurônios Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Bélgica