Lipoprotein(a) and atherogenesis.

ABSTRACT

Lipoprotein(a) is a major inherited risk factor for atherosclerosis. Many of its activities depend on its plasminlike component, apolipoprotein(a). In vitro studies suggest that apolipoprotein(a) could enhance lipid deposition through binding to sites in the vessel wall, interfere with fibrinolysis, and modulate smooth muscle cell activity. Human and animal studies will be necessary to establish the physiologic importance of these mechanisms.