Transmission of classical scrapie to wild-type mice: the influence of the ovine PrP sequence on lesion profiles.
Arch Virol
; 156(5): 903-6, 2011 May.
Article
em En
| MEDLINE
| ID: mdl-21293966
ABSTRACT
Susceptibility of sheep to classical scrapie is determined by polymorphisms in the coding region of the prion protein gene (PRNP), mainly at codons 136, 154 and 171. It has recently been shown that lesion profiles from classical field scrapie isolates that transmitted to RIII mice can be classified into different groups. There was also strong, but not absolute, association between the different groups and codon 136. Here, we examine the hypothesis that additional polymorphisms in the open reading frame sequence of the ovine PRNP may account for the different groups of lesion profiles observed following transmission to mice.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Scrapie
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Doenças dos Ovinos
/
Príons
Limite:
Animals
Idioma:
En
Revista:
Arch Virol
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Reino Unido