[Deimination or citrullination, a post-translational modification with many physiological and pathophysiological facets]. / La désimination ou citrullination: une modification post-traductionnelle aux multiples facettes.
Med Sci (Paris)
; 27(1): 49-54, 2011 Jan.
Article
em Fr
| MEDLINE
| ID: mdl-21299962
ABSTRACT
Deimination or citrullination, is a post-translational modification with many facets. It is involved in several basic cellular processes, including gene regulation, embryonic development and terminal differentiation, and also in various pathophysiological mechanisms linked to severe human diseases such as multiple sclerosis and rheumatoid arthritis. Deimination, the calcium-dependent enzymatic conversion of peptidyl-arginine to peptidyl-citrulline, induces a decrease in the charge of the modified proteins with major consequences on their conformation, stability and/or interactions, and therefore on their functions. Five isotypes of peptidylarginine deiminases (1-4 and 6), exist in humans with a variable tissue expression. These highly conserved enzymes are closely regulated at transcriptional and post-transcriptional levels, probably including auto-deimination.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Arginina
/
Processamento de Proteína Pós-Traducional
/
Citrulina
/
Hidrolases
Limite:
Animals
/
Humans
Idioma:
Fr
Revista:
Med Sci (Paris)
Assunto da revista:
MEDICINA
Ano de publicação:
2011
Tipo de documento:
Article