PEGylation prevents bacteria-induced platelet activation and biofilm formation in platelet concentrates.
Vox Sang
; 100(3): 336-9, 2011 Apr.
Article
em En
| MEDLINE
| ID: mdl-21392023
ABSTRACT
Bacterial contamination of platelet concentrates represents the greatest post-transfusion infectious risk. Biofilm formation in this environment resulting from platelet-bacteria interactions can lead to non-uniform contaminant distribution and thus missed detection. As formation of platelet-bacteria aggregates is largely based on receptor-ligand interactions, we examined whether shielding these events would result in reduced biofilm formation by contaminant bacteria. We introduced methoxypoly(ethylene glycol) to covalently modify the platelet surface using a process termed 'PEGylation'. In the first study of its kind, we demonstrate that PEGylated platelet concentrates inoculated with Staphylococcus epidermidis display a significant reduction in bacterial binding and biofilm formation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polietilenoglicóis
/
Bactérias
/
Plaquetas
/
Preservação de Sangue
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Ativação Plaquetária
/
Biofilmes
Limite:
Humans
Idioma:
En
Revista:
Vox Sang
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Canadá