The procoagulant effects of fine particulate matter in vivo.
Part Fibre Toxicol
; 8: 12; author reply 12, 2011 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-21406084
ABSTRACT
Inhalation of fine particulate matter (<2.5 µm; fine PM) has been shown to increase the risk for cardiovascular events. In this letter, we reappraise the role of tissue factor (TF) antigen and we also summarize changes in measured coagulation proteins in humans and rodents by other studies with fine PM. By considering all studies including ours, we conclude that monitoring the overall coagulation state by measuring capacity assays such as thrombin generation, and quantification of TF activity would be more suitable than determining single coagulation proteins (such as TF antigen) in order to better assess the systemic prothrombotic effects of fine PM.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Coagulação Sanguínea
/
Tromboplastina
/
Material Particulado
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Part Fibre Toxicol
Assunto da revista:
TOXICOLOGIA
Ano de publicação:
2011
Tipo de documento:
Article