A role for the small GTPase Rab6 in assembly of human cytomegalovirus.
J Virol
; 85(10): 5213-9, 2011 May.
Article
em En
| MEDLINE
| ID: mdl-21411515
ABSTRACT
In human-cytomegalovirus (HCMV)-infected cells, the localization of the viral protein pp150 to the virus assembly compartment (AC) is dependent on its direct interaction with the cellular protein Bicaudal D1 through a dynein- and microtubule-dependent mechanism. We found that the small GTPase Rab6 also interacts indirectly with pp150 through its interaction with Bicaudal D1. Inhibition of Rab6 activity in HCMV-infected cells interrupted the intracellular trafficking of pp150, significantly reducing infectious virus production without affecting the formation of the AC, arguing for an important function for this cellular GTPase in the intracellular localization of pp150 during virus assembly.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfoproteínas
/
Proteínas da Matriz Viral
/
Montagem de Vírus
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Proteínas rab de Ligação ao GTP
/
Citomegalovirus
/
Interações Hospedeiro-Patógeno
Limite:
Humans
Idioma:
En
Revista:
J Virol
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos