Risk factors for hand, foot, and mouth disease and herpangina and the preventive effect of hand-washing.
Pediatrics
; 127(4): e898-904, 2011 Apr.
Article
em En
| MEDLINE
| ID: mdl-21422083
ABSTRACT
BACKGROUND:
Hygiene and social distancing are recommended control measures for hand, foot, and mouth disease (HFMD) and herpangina. However, empirical data to support this recommendation are limited.METHODS:
During an outbreak of HFMD and herpangina due to infection by the human enterovirus 71, we defined a case as a vesicular papular rash on the hands, feet, buttocks, or oral mucosa and onset from April 30 to June 26, 2008. We selected 176 HFMD and herpangina case-children and a stratified random sample of 201 asymptomatic control-children; frequency matched according to residency status. We administered a questionnaire to the parents about their children's exposures and hygienic behaviors.RESULTS:
Risk factors for HFMD and herpangina included playing with neighborhood children (odds ratio [OR] 11 [95% confidence interval (CI) 6.2-17]), visiting an outpatient clinic for another reason ≤ 1 week before onset (OR 20 [95% CI 5.0-88]), and community exposures to crowded places (OR 7.3 [95% CI 4.1-13]). By using a score summarizing responses to 4 hand-washing questions, we found that 50% of the case-children and 2.5% of control-children had a poor score of 1 to 3, whereas 12% of the case-children and 78% of control-children had a good score of ≥ 7 (OR 0.00069 [95% CI 0.0022-0.022]) after we adjusted for residency, age, and community exposures by using logistic regression.CONCLUSIONS:
Hand-washing by preschool-aged children and their caregivers had a significant protective effect against community-acquired HFMD and herpangina from the human enterovirus 71 infection.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Desinfecção das Mãos
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Surtos de Doenças
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Doença de Mão, Pé e Boca
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Herpangina
Tipo de estudo:
Etiology_studies
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Guideline
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Incidence_studies
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Observational_studies
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Prevalence_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Child
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Child, preschool
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Female
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Humans
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Infant
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Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
Pediatrics
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
China