Impairment of kidney function and reduced quality-of-life in older people: a cross-sectional study.
Age Ageing
; 40(3): 381-7, 2011 May.
Article
em En
| MEDLINE
| ID: mdl-21427113
ABSTRACT
OBJECTIVE:
to assess the association of kidney function with quality-of-life in community-dwelling older adults aged 75 years or more in the UK.DESIGN:
cross-sectional study.SETTING:
primary care; 12 UK general practices participating in a cluster trial of health screening.SUBJECTS:
estimated glomerular filtration rate (eGFR, ml/min/1.73 m(2)) using the four-variable modified diet in renal disease equation was derived in 1,195 men and 1,772 women with available bloods, these were 92% of 3,211 study participants who consented to interviews and 73% of those invited into the original cluster trial of health screening. MAIN OUTCOMEMEASURES:
interviews by trained fieldworker using the Sickness Impact Profile (home management, mobility, self-care, social interaction), and the Philadelphia Geriatric Morale Scale. Higher scores imply worse quality-of-life in a given domain.RESULTS:
in age- and co-morbidity-adjusted analyses there was an association of eGFR <45 and the highest scores (defined as ≥median) of mobility (men odds ratio (OR) 2.91, 95% confidence interval (CI) 1.56-5.41; women OR 1.73, 95% CI 1.02-2.94), home management (men OR 1.49, 95% CI 1.09-2.04; women OR 3.50, 95% CI 1.18-10.35), social interaction (men OR 3.34, 95% CI 1.73-6.45; women 2.64, 95% CI 1.61-4.33) when compared with those with eGFR ≥60 and who reported no problems. Men with eGFR <45 had low morale (OR 2.45, 95% CI 1.02-5.87) but this was not found for women (OR 1.40, 95% CI 0.65-3.04), whereas women (but not men) with eGFR <45 reported problems with body care (women OR 1.68; 95% CI 1.25-2.27 men OR 0.89, 95% CI 0.55-1.46).CONCLUSIONS:
an eGFR <45 is associated with poorer quality-of-life at older age. More research is needed to identify modifiable causes to improve quality-of-life in older people with such a degree of kidney function impairment.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Qualidade de Vida
/
Características de Residência
/
Nível de Saúde
/
Taxa de Filtração Glomerular
/
Nefropatias
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
Age Ageing
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Reino Unido