A modified CDC biofilm reactor to produce mature biofilms on the surface of peek membranes for an in vivo animal model application.
Curr Microbiol
; 62(6): 1657-63, 2011 Jun.
Article
em En
| MEDLINE
| ID: mdl-21437591
ABSTRACT
Biofilm-related infections have become a major clinical concern. Typically, animal models that involve inoculation with planktonic bacteria have been used to create positive infection signals and examine antimicrobial strategies for eradicating or preventing biofilm-related infection. However, it is estimated that 99.9% of bacteria in nature dwell in established biofilms. As such, open wounds have significant potential to become contaminated with bacteria that reside in a well-established biofilm. In this study, a modified CDC biofilm reactor was developed to repeatably grow mature biofilms of Staphylococcus aureus on the surface of polyetheretherketone (PEEK) membranes for inoculation in a future animal model of orthopaedic implant biofilm-related infection. Results indicated that uniform, mature biofilms repeatably grew on the surface of the PEEK membranes.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções Relacionadas à Prótese
/
Biofilmes
/
Reatores Biológicos
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Staphylococcus aureus Resistente à Meticilina
/
Traumatismos do Joelho
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Microbiol
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos