Maternal thyroid function during pregnancy and behavioral problems in the offspring: the generation R study.
Pediatr Res
; 69(5 Pt 1): 454-9, 2011 May.
Article
em En
| MEDLINE
| ID: mdl-21471776
ABSTRACT
Maternal thyroid function during pregnancy is implicated in the neurodevelopment of the offspring, yet little is known about the effect of maternal thyroid parameters on the behavior of children. We investigated the association of maternal thyroid function during the first half of pregnancy with parent-reported problem behavior of the offspring up to age of 3 y. In the Generation R study, a population-based cohort of 3736 children and their mothers, data on maternal thyroid function and child's behavior were examined. The degree of internalizing and externalizing problems in the children were assessed with the Child Behavior Checklist at ages 1½ and 3 y. Higher levels of maternal TSH during pregnancy predicted a higher externalizing scores in children at 1½ and 3 y (B = 0.22 per SD of TSH; 95% CI 0.04, 0.40; B = 0.10 per SD for internalizing scores; 95% CI -0.01, 0.21). Maternal free thyroxine (T4) and total T4 were not associated with internalizing or externalizing scores of children. The linear relationship with more externalizing scores was across the range of TSH; this implies that subtle impairments of maternal thyroid function may affect the child. The results suggest that thyroid function is crucial for fetal brain development, which determines problem behavior later in life.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Efeitos Tardios da Exposição Pré-Natal
/
Glândula Tireoide
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Tiroxina
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Tireotropina
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Comportamento Infantil
/
Transtornos do Comportamento Infantil
/
Comportamento do Lactente
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Child, preschool
/
Female
/
Humans
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Infant
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Male
/
Pregnancy
País/Região como assunto:
Europa
Idioma:
En
Revista:
Pediatr Res
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Holanda