Desferrioxamine as a lipid chain-breaking antioxidant in sickle erythrocyte membranes.
FEBS Lett
; 264(1): 145-8, 1990 May 07.
Article
em En
| MEDLINE
| ID: mdl-2159892
ABSTRACT
The mechanism of action of desferrioxamine in the inhibition of the catalysis of iron-induced oxidative damage has been ascribed to its ability to chelate available ferric ion (Kb = 10(31)). However, recent work has proposed that the trihydroxamate moiety of desferrioxamine can also be involved in electron transfer reactions involving the superoxide radical, peroxidase/hydrogen peroxide mixtures and ferryl myoglobin radicals. In this study we report evidence for the ability of desferrioxamine to inhibit peroxidative damage to pathological membranes with which non-haem iron is associated through a mechanism of action as a lipid chain breaking antioxidant, independently of its iron chelating properties.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Desferroxamina
/
Membrana Eritrocítica
/
Anemia Falciforme
/
Peróxidos Lipídicos
/
Lipídeos de Membrana
/
Antioxidantes
Limite:
Humans
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Reino Unido