Mechanism of action of a new macromolecular antitumor antibiotic, C-1027.
J Antibiot (Tokyo)
; 43(4): 417-21, 1990 Apr.
Article
em En
| MEDLINE
| ID: mdl-2161819
ABSTRACT
C-1027 is a new antitumor protein antibiotic containing a non-protein chromophore. The active moiety and the mechanism of action of this antibiotic were studied. C-1027 and its chromophore inhibited the growth of KB carcinoma and L1210 leukemia cells, even at extremely low concentrations. C-1027 inhibited DNA synthesis of L1210 cells and cleaved cellular DNA in a drug concentration-dependent manner. C-1027 and chromophore caused directly DNA single strand breaks in the purified DNA without any supplement of reducing agents. These results suggest that C-1027 chromophore may inhibit cell growth by causing DNA breakage with subsequent inhibition of DNA synthesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dano ao DNA
/
DNA de Neoplasias
/
Aminoglicosídeos
/
Antibacterianos
/
Antibióticos Antineoplásicos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Antibiot (Tokyo)
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Japão