Isolation and characterization of an immunoenhancing glucan from alkaline extract of an edible mushroom, Lentinus squarrosulus (Mont.) Singer.
Carbohydr Res
; 346(13): 2039-44, 2011 Sep 27.
Article
em En
| MEDLINE
| ID: mdl-21722881
ABSTRACT
A water-soluble glucan, isolated from the alkaline extract of the fruit bodies of an edible mushroom, Lentinus squarrosulus (Mont.) Singer was found to consist of (1â3,6)-linked, (1â3)-linked, (1â6)-linked, and terminal ß-d-glucopyranosyl moieties in a relative proportion of approximately 1211. This polysaccharide showed optimum activation of macrophages as well as splenocytes and thymocytes at 10µg/mL. Structural investigation was carried out using sugar analysis, methylation analysis, periodate oxidation study, and NMR experiments ((1)H, (13)C, DEPT-135, DQF-COSY, TOCSY, NOESY, ROESY, HMQC, and HMBC). On the basis of above-mentioned experiments, the structure of the repeating unit of the polysaccharide was established as
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Adjuvantes Imunológicos
/
Lentinula
/
Agaricales
/
Glucanos
Limite:
Animals
Idioma:
En
Revista:
Carbohydr Res
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Índia