Histone ADP-ribosylation in DNA repair, replication and transcription.
Trends Cell Biol
; 21(9): 534-42, 2011 Sep.
Article
em En
| MEDLINE
| ID: mdl-21741840
ABSTRACT
Most published work on post-translational histone modifications focuses on small covalent alterations such as acetylation, methylation and phosphorylation. By contrast, fewer data are available on the modification of histones by ADP-ribose. Discussion of the biological significance of histone ADP-ribosylation has often been restricted to functions of the modifying enzymes, rather than to histones as ADP-ribose acceptors. In particular, the identification of specific lysine residues as ADP-ribose acceptor sites in histones and the identification of ADP-ribose binding modules raise this modification to a par with acetylation, methylation or phosphorylation. We discuss here the functional aspects of histone ADP-ribosylation and its influence on DNA repair, replication and transcription.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
/
Histonas
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Adenosina Difosfato Ribose
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Reparo do DNA
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Replicação do DNA
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Cell Biol
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Suíça