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Molecular analysis of population structure and antibiotic resistance of Klebsiella isolates from a three-year surveillance program in Florence hospitals, Italy.
Donnarumma, F; Indorato, C; Mastromei, G; Goti, E; Nicoletti, P; Pecile, P; Fanci, R; Bosi, A; Casalone, E.
Afiliação
  • Donnarumma F; CIBIACI and Department of Evolutionary Biology, University of Florence, Via Romana 17/19, 50125, Florence, Italy.
Eur J Clin Microbiol Infect Dis ; 31(3): 371-8, 2012 Mar.
Article em En | MEDLINE | ID: mdl-21744038
ABSTRACT
We report the results of a three-year surveillance program of Klebsiella spp. in six hospitals in Florence (Italy). A total of 172 Klebsiella isolates were identified and typed by AFLP 122 were K. pneumoniae and 50 were K. oxytoca. Most K. pneumoniae (80%) and K. oxytoca (93%) showed unrelated AFLP profiles. Beside this heterogeneous population structure, we found five small epidemic clonal groups of K. pneumoniae. Four of these groups were involved in outbreak events, three of which occurred in neonatal ICUs. The fifth clonal group spread in three different wards of two hospitals. Only one non-epidemic clonal group of K. oxytoca was detected. The frequencies of isolates with multiple antibiotic resistances increased with time; at the end of the study period, most K. pneumoniae were resistant to all the antibiotics tested. A PCR analysis of seven ertapenem resistant isolates was unable to detect any of the major genes known to underlie carbapenem resistance in K. pneumoniae.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Klebsiella / Farmacorresistência Bacteriana Múltipla / Klebsiella Tipo de estudo: Screening_studies Limite: Humans País/Região como assunto: Europa Idioma: En Revista: Eur J Clin Microbiol Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Itália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Klebsiella / Farmacorresistência Bacteriana Múltipla / Klebsiella Tipo de estudo: Screening_studies Limite: Humans País/Região como assunto: Europa Idioma: En Revista: Eur J Clin Microbiol Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Itália