Nicotine's central cardiovascular actions: receptor subtypes involved and their possible physiological role in anaesthetized rats.
Eur J Pharmacol
; 668(1-2): 177-83, 2011 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-21763305
ABSTRACT
Centrally applied nicotine causes changes in blood pressure and vasopressin release. The involvement of different neuronal nicotinic receptor subtypes in these actions was investigated in anaesthetized rats. Nicotine administered i.c.v. caused a dose-related increase in blood pressure and renal sympathoinhibition, while i.c. administration also caused a bradycardia. In the presence of the V(1A) receptor antagonist (i.v.), nicotine (i.c) now caused a depressor response along with sympathoinhibition and bradycardia. Nicotine (0.3 µmol/kg; i.c.v.) in the presence of the α4ß2 receptor antagonist, dihydro-ß-erythroidine, (i.c.v.) evoked renal sympathoexcitation, while the α7 receptor antagonist, methyllycaconitine, delayed the expected sympathoinhibition. Both receptor antagonists blocked the pressor response. Dihydro-ß-erythroidine (i.c., 10µmol/kg) alone caused a transient pressor response and increased renal nerve activity. Methyllycaconitine (i.c., 0.1 µmol/kg) alone caused a slow fall in blood pressure and renal nerve activity, while the higher doses caused a pressor response and increased renal nerve activity. It was concluded that for nicotine to release vasopressin, activation of both α4ß2 and α7 receptors is required. The ability of nicotine to cause sympathoinhibition is mediated by ß4*-containing receptors, possibly α3ß4 receptors, and that activation of these receptors can override the sympathoexcitatory action of α4ß2 and α7 receptors. The ability of dihydro-ß-erythroidine and high doses of methyllycaconitine i.c. to cause sympathoexcitation and a pressor response is due to receptor antagonists blocking these sympathoinhibitory ß4*-containing receptors, which receive a tonic cholinergic input. As the low dose of methyllycaconitine caused sympathoinhibition, this indicates that sympathoexcitatory α7 receptors also receive a tonic input.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistema Cardiovascular
/
Receptores Nicotínicos
/
Anestesia
/
Nicotina
Limite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
2011
Tipo de documento:
Article