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Association of Fcγ receptor IIIA variant with a subset of anti-topoisomerase I-positive patients in systemic sclerosis: a descriptive pilot study.
Magnant, J; Ohresser, M; Allanore, Y; de Monte, M; Lafosse-Marin, M; Degenne, D; Guilmot, J L; Watier, H; Diot, E.
Afiliação
  • Magnant J; Service de Médecine Interne et Vasculaire B, CHRU de Tours, France, Tours, France. magnant@med.univ-tours.fr
Rheumatol Int ; 32(7): 2203-7, 2012 Jul.
Article em En | MEDLINE | ID: mdl-21785957
Hypothesizing a pathophysiological role of anti-topoisomerase I antibodies (anti-topo I) through autoantibody-dependent cell-mediated cytotoxicity (ADCC) and cytotoxic effectors expressing receptors for the Fc portion of IgG in systemic sclerosis (SSc), 267 SSc patients (56 with anti-topo I and 102 with anti-centromere antibodies (ACA)) were genotyped for the functional FCGR3A-V158F polymorphism. A descriptive analysis of patients according to their clinical and immunological status and FCGR3A-158 V/F genotypes was performed using multiple correspondence analysis. This descriptive analysis revealed an association between the FCGR3A-158 VV genotype and the presence of anti-topo I. By contrast, no relationship was found between FCGR3A polymorphism and the presence of ACA. SSc patients with anti-topo I appear to be more frequently homozygous for the high-affinity FcγRIIIA-coding allele, suggesting that some autoantibodies may be pathogenic through ADCC.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Escleroderma Sistêmico / Receptores de IgG / DNA Topoisomerases Tipo I / Estudos de Associação Genética Tipo de estudo: Risk_factors_studies Limite: Adult / Aged / Humans / Male / Middle aged Idioma: En Revista: Rheumatol Int Ano de publicação: 2012 Tipo de documento: Article País de afiliação: França

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Escleroderma Sistêmico / Receptores de IgG / DNA Topoisomerases Tipo I / Estudos de Associação Genética Tipo de estudo: Risk_factors_studies Limite: Adult / Aged / Humans / Male / Middle aged Idioma: En Revista: Rheumatol Int Ano de publicação: 2012 Tipo de documento: Article País de afiliação: França