A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?
Cell
; 146(3): 353-8, 2011 Aug 05.
Article
em En
| MEDLINE
| ID: mdl-21802130
ABSTRACT
Here, we present a unifying hypothesis about how messenger RNAs, transcribed pseudogenes, and long noncoding RNAs "talk" to each other using microRNA response elements (MREs) as letters of a new language. We propose that this "competing endogenous RNA" (ceRNA) activity forms a large-scale regulatory network across the transcriptome, greatly expanding the functional genetic information in the human genome and playing important roles in pathological conditions, such as cancer.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
RNA
/
Perfilação da Expressão Gênica
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cell
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos