[Comparison of two initial mobilizing strategies of peripheral blood stem cells for autologous transplantation in patients with lymphoma and human immunodeficiency virus infection]. / Comparación de dos estrategias iniciales de movilización de progenitores hematopoyéticos de sangre periférica para trasplante autogénico en pacientes con linfomas e infección por el virus de la inmunodeficiencia humana.
Med Clin (Barc)
; 139(5): 192-6, 2012 Jul 21.
Article
em Es
| MEDLINE
| ID: mdl-21807388
ABSTRACT
BACKGROUND AND OBJECTIVE:
Several studies have demonstrated the feasibility of autologous stem cell transplantation (ASCT) in patients with lymphoma and human immunodeficiency virus (HIV) infection. HIV infection has been described as a risk factor for poor mobilization. The aim of this study was to compare the results of two mobilization strategies of peripheral blood stem cells (PBSC) in patients with lymphoma and HIV infection in seven Spanish hospitals. PATIENTS ANDMETHODS:
The following variables were collected demographic, clinical and biological features, previous chemotherapies and outcomes, as well as mobilization's strategies (classified in two groups 1) G-CSF, and 2) G-CSF + chemotherapy).RESULTS:
Between January 2000 and May 2010, 42 patients with lymphoma and HIV infection were referred for ASCT. The rate of successful mobilization (collection >1.60 × 10(6) CD34 cells/kg) with the first regimen was 67%, with no differences between those patients mobilized with G-CSF or with G-CSF + chemotherapy (16 [72%] and 12 [60%], respectively; p=0.382). The status of the lymphoma at the time of mobilization was the only factor for successful mobilization (20/22 patients [91%] in complete remission [CR] mobilized adequately versus 5/12 [58%] in partial remission [PR]; p=0.038).CONCLUSIONS:
In patients with lymphoma and HIV infection, mobilization with G-CSF was as effective as mobilization with chemotherapy followed by G-CSF. The stage of disease prior to the mobilization was the main risk factor for the success of mobilization, with better results in patients mobilized in remission of the lymphoma.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fator Estimulador de Colônias de Granulócitos
/
Linfoma Relacionado a AIDS
/
Mobilização de Células-Tronco Hematopoéticas
/
Transplante de Células-Tronco de Sangue Periférico
Tipo de estudo:
Evaluation_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Es
Revista:
Med Clin (Barc)
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Espanha