Sun exposure, vitamin D intake and progression to disability among veterans with progressive multiple sclerosis.
Neuroepidemiology
; 37(1): 52-7, 2011.
Article
em En
| MEDLINE
| ID: mdl-21822026
ABSTRACT
BACKGROUND:
Early life events have been suggested to influence multiple sclerosis (MS) susceptibility, and to potentially modulate its clinical course. We assessed vitamin D-related exposures from childhood to disease onset and their associations with MS progression.METHODS:
Among veterans in the Multiple Sclerosis Surveillance Registry, 219 reported having the progressive form and met the inclusion criteria. Participants reported their past sun exposure, vitamin D-related intake and age at disability milestones using the Patient-Determined Disease Steps (PDDS). The Cox proportional hazards model was used to examine the association between vitamin D-related exposures and time (years) to disability.RESULTS:
Low average sun exposure in the fall/winter before disease onset was associated with an increased risk of progressing to a PDDS score of 8 (hazard ratio, HR 2.13, 95% confidence interval, CI 1.20-3.78), whereas use of cod liver oil during childhood and adolescence was associated with a reduced risk (HR 0.44, 95% CI 0.20-0.96).CONCLUSIONS:
These results suggest that exposure to vitamin D before MS onset might slow disease-related neurodegeneration and thus delay progression to disability among patients with the progressive subtype.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Luz Solar
/
Vitamina D
/
Progressão da Doença
/
Esclerose Múltipla Crônica Progressiva
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Neuroepidemiology
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos