Is the prophylaxis of patent ductus arteriosus useful in extremely premature infants?
Turk J Pediatr
; 53(2): 187-93, 2011.
Article
em En
| MEDLINE
| ID: mdl-21853657
ABSTRACT
This study was aimed to verify the efficacy and safety of ibuprofen prophylaxis of patent ductus arteriosus in very preterm infants, in order to select infants receiving higher benefits from this intervention. Two hundred neonates with gestational age (GA) < or = 28 weeks receiving ibuprofen within the first two hours of life were included. Ductus closure rate was 68%, and results were significantly dependent on GA (48.8% among neonates with GA < 26 weeks vs 73.2% among those with GA > or = 26 weeks, p < 0.01). Neonates with GA < 26 weeks showed a lower ductus closure after the primary course of therapy (20% vs 57.5%, p < 0.01), as well as higher reopening rate (16.2% vs 3.8%, p < 0.05) and need for surgical ligation (38.8% vs 5.8%, p < 0.01). During the prophylaxis period, 11 neonates (5.5%) showed pulmonary hypertension. Considering risks/benefits, we recommend prophylaxis only in infants with GA < 26 weeks.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ibuprofeno
/
Inibidores de Ciclo-Oxigenase
/
Permeabilidade do Canal Arterial
/
Doenças do Prematuro
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
/
Newborn
Idioma:
En
Revista:
Turk J Pediatr
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Itália