C-myc, N-myc, N-ras, and c-erb-B: lack of amplification or rearrangement in human medullary thyroid carcinoma and a derivative cell line.
Anticancer Res
; 10(1): 189-92, 1990.
Article
em En
| MEDLINE
| ID: mdl-2185686
ABSTRACT
We investigated the copy number and possible rearrangement of the four protooncogenes, c-myc, N-myc, N-ras, and c-erb-B, in DNA from seven untreated primary cancers or metastases of medullary thyroid carcinoma and an established human medullary thyroid carcinoma cell line, TT, using the Southern blotting technique. The purpose of this study was two-fold 1) to examine whether protooncogene perturbations in medullary thyroid carcinoma could be considered as a prognostic marker; and 2) to determine whether the protooncogenes could have a possible role in medullary thyroid tumorigenesis. Neither amplification nor rearrangement of the protooncogenes was detectable in the DNA from any tumor samples or in the cell line. Our results suggest that DNA-evident amplification and rearrangement of the c-myc, N-myc, N-ras, and c-erb-B oncogenes may not be mechanisms through which these oncogenes become activated in this malignancy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proto-Oncogenes
/
Neoplasias da Glândula Tireoide
/
Carcinoma
/
Rearranjo Gênico
/
Amplificação de Genes
/
Proteínas Proto-Oncogênicas
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Anticancer Res
Ano de publicação:
1990
Tipo de documento:
Article