Synthesis of 2,4,6-trisubstituted pyridines via an olefin cross-metathesis/Heck-cyclisation-elimination sequence.

ABSTRACT

Heck reactions were performed on α,ß-unsaturated-δ-sulfonamido intermediates, derived from cross metathesis, to allow the instalment of substituents at the ß position. Subsequent one-pot cyclisation/elimination provides an operationally simple, catalytic and convergent synthesis of 2,4,6-trisubstituted pyridines.