[Slowing chronic kidney disease progression: hopes and disappointments. Vascular repair of chronic kidney]. / Ralentir la progression de l'insuffisance rénale chronique: espoirs et déceptions. La réparation vasculaire du rein chronique.
Presse Med
; 40(11): 1065-73, 2011 Nov.
Article
em Fr
| MEDLINE
| ID: mdl-21889290
ABSTRACT
In chronic kidney disease patients, inexorable renal function decline is reduced by renin-angiotensin system (RAS) blockers. ACE inhibitors and angiotensin receptor blockers decrease blood pressure and proteinuria. Guidelines recommend a reduction of blood pressure to less than 130/80 mmHg and urinary protein excretion below 0.5 g/d. The combined use of a diuretic increases anti-proteinuric effect and blood pressure control of RAS blockers. Drugs as mineralo-corticocoids receptor antagonist and endothelin receptor antagonists reduce further albuminuria in combination with RAS blocker, but side effects need to be precised. Both metabolic acidosis and hyperuricemia represent new therapeutic goals to slow renal function decline in CKD patients. Renal fibrosis treatment and regenerative medicine are stemming and will be important issues for kidney and other organs in the future.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistema Renina-Angiotensina
/
Inibidores da Enzima Conversora de Angiotensina
/
Bloqueadores do Receptor Tipo 1 de Angiotensina II
/
Diuréticos
/
Rim
/
Falência Renal Crônica
/
Anti-Hipertensivos
Tipo de estudo:
Guideline
Limite:
Humans
Idioma:
Fr
Revista:
Presse Med
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
França