Prostate MRI: diffusion-weighted imaging at 1.5T correlates better with prostatectomy Gleason Grades than TRUS-guided biopsies in peripheral zone tumours.
Eur Radiol
; 22(2): 468-75, 2012 Feb.
Article
em En
| MEDLINE
| ID: mdl-21913058
ABSTRACT
OBJECTIVES:
To investigate the usefulness of Apparent Diffusion Coefficients (ADC) in predicting prostatectomy Gleason Grades (pGG) and Scores (GS), compared with ultrasound-guided biopsy Gleason Grades (bGG).METHODS:
Twenty-four patients with biopsy-proven prostate cancer were included in the study. Diffusion-weighted images were obtained using 1.5-T MR with a pelvic phased-array coil. Median ADC values (b0,500,1000 s/mm²) were measured at the most suspicious areas in the peripheral zone. The relationship between ADC values and pGG or GS was assessed using Pearson's coefficient. The relationship between bGG and pGG or GS was also evaluated. Receiver operating characteristic (ROC) curve analysis was performed to assess the performance of each method on a qualitative level.RESULTS:
A significant negative correlation was found between mean ADCs of suspicious lesions and their pGG (r = -0.55; p < 0.01) and GS (r = -0.63; p < 0.01). No significant correlation was found between bGG and pGG (r = 0.042; p > 0.05) or GS (r = 0.048; p > 0.05). ROC analysis revealed a discriminatory performance of AUC = 0.82 for ADC and AUC = 0.46 for bGG in discerning low-grade from intermediate/high-grade lesions.CONCLUSIONS:
The ADC values of suspicious areas in the peripheral zone perform better than bGG in the correlation with prostate cancer aggressiveness, although with considerable intra-subject heterogeneity. KEY POINTS ⢠Prostate cancer aggressiveness is probably underestimated and undersampled by routine ultrasound-guided biopsies. ⢠Diffusion-weighted MR images show good linear correlation with prostate cancer aggressiveness. ⢠DWI information may be used to improve risk-assessment in prostate cancer.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Próstata
/
Neoplasias da Próstata
/
Ultrassonografia
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Imagem de Difusão por Ressonância Magnética
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Ultrassom Focalizado Transretal de Alta Intensidade
Tipo de estudo:
Diagnostic_studies
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Observational_studies
/
Prognostic_studies
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Qualitative_research
/
Risk_factors_studies
Limite:
Aged
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Eur Radiol
Assunto da revista:
RADIOLOGIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Brasil