Significance of specific IgG against sensitizing antigens in extrinsic allergic alveolitis: serological methods in EAA.
Rev Port Pneumol
; 17(6): 253-9, 2011.
Article
em En, Pt
| MEDLINE
| ID: mdl-21924863
ABSTRACT
The aim of our study is to find differences in IgG in sera of potentially exposed and nonexposed individuals and to detect differences in concentrations of specific serum IgG among subjects with and without EAA. Seventy-two patients being followed for suspected interstitial lung disease were included. Specific IgG in sera were established by ImmunoCAP. Serum concentrations of Aspergillus fumigatus, Candida albicans IgG and mixture of moulds IgG were higher in subjects with exposure to relevant inhalation antigens (p<0.05). Patients exposed to parrot and mammal hair mixture had higher serum concentration of specific IgG (p<0.05). Subjects without exposure to mites had lower serum IgG to Dermatophagoides pteronyssinus, Dermatophagoides farinae, Dermatophagoides microceras and Glycophagus domesticus (p<0.05). Higher concentration of serum specific IgG may show previous exposure to this antigen. Even though mite specific IgG are not commonly tested in EAA patients, we suggest their immunomodulatory activity may influence susceptibility to other inhalation antigens.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina G
/
Alveolite Alérgica Extrínseca
/
Antígenos
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
/
Pt
Revista:
Rev Port Pneumol
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
República Tcheca