Inhibition of protein-protein interactions with low molecular weight compounds.
Curr Trends Med Chem
; 5: 21-32, 2008 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-21927717
ABSTRACT
An overview of issues associated with the design and development of low molecular weight inhibitors of protein-protein interactions is presented. Areas discussed include information on the nature of protein-protein interfaces, methods to characterize those interfaces and methods by which that information is applied towards ligand identification and design. Specific examples of the strategy for the identification of inhibitors of protein-protein interactions involving the proteins p56lck kinase, ERK2 and the calcium-binding protein S100B are presented. Physical characterization of the inhibitors identified in those studies shows them to have drug-like and lead-like properties, indicating their potential to be developed into therapeutic agents.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Curr Trends Med Chem
Ano de publicação:
2008
Tipo de documento:
Article