Reactive oxygen species driven angiogenesis by inorganic nanorods.
Nano Lett
; 11(11): 4932-8, 2011 Nov 09.
Article
em En
| MEDLINE
| ID: mdl-21967244
ABSTRACT
The exact mechanism of angiogenesis by europium hydroxide nanorods was unclear. In this study we have showed that formation of reactive oxygen species (H(2)O(2) and O(2)·-) is involved in redox signaling pathways during angiogenesis, important for cardiovascular and ischemic diseases. Here we used single-walled carbon nanotube sensor array to measure the single-molecule efflux of H(2)O(2) and a HPLC method for the determination of O(2)·- from endothelial cells in response to proangiogenic factors. Additionally, reactive oxygen species-mediated angiogenesis using inorganic nanorods was observed in transgenic (fli1aEGFP) zebrafish embryos.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Espécies Reativas de Oxigênio
/
Neovascularização Fisiológica
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Células Endoteliais
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Nanopartículas
/
Compostos Inorgânicos
Limite:
Humans
Idioma:
En
Revista:
Nano Lett
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Índia