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Deletion of the late cornified envelope genes LCE3B and LCE3C may promote chronic hand eczema with allergic contact dermatitis.
Molin, S; Vollmer, S; Weiss, E H; Weisenseel, P; Ruzicka, T; Prinz, J C.
Afiliação
  • Molin S; Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany. sonja.molin@med.uni-muenchen.de
Article em En | MEDLINE | ID: mdl-21995181
BACKGROUND: Genetically determined defects in epidermal skin barrier function may contribute to the development of irritant and/or allergic contact dermatitis in chronic hand eczema (CHE). OBJECTIVES: To assess whether a deletion in the late cornified envelope genes LCE3B and LCE3C may constitute a genetic predisposition for the development of CHE or any of its subtypes. PATIENTS AND METHODS: A total of 153 German patients with clearly defined CHE subtypes and 268 healthy individuals were screened for the deletion LCE3C_LCE3B-del by allele-specific polymerase chain reaction. RESULTS: Classification of the patients by etiologic subtypes revealed an association between the LCE3C_LCE3B-del allele and CHE due to allergic contact dermatitis. In this subtype, 19/37 patients (51.4%) were homozygous deletion carriers, 11/37 (29.7%) were heterozygous carriers, and just 7/37 (18.9%) were wild-type individuals. Compared to the other CHE subgroups and the healthy control group (homozygous, 88/268 [32.83%]; heterozygous, 133/268 [49.63%]; and wild-type, 47/268 [17.54%]), the prevalence of LCE3C_LCE3B-del in these patients reached statistical significance (P = .03977), as did homozygous deletion carrier status (P = .01044 for other subtypes and P = .02695 for controls). CONCLUSIONS: A deletion of LCE genes may promote the development of allergic contact dermatitis, which is a form of CHE involving delayed-type hypersensitivity.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Deleção de Genes / Dermatite Alérgica de Contato / Predisposição Genética para Doença / Proteínas Ricas em Prolina do Estrato Córneo Tipo de estudo: Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Investig Allergol Clin Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Alemanha
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Deleção de Genes / Dermatite Alérgica de Contato / Predisposição Genética para Doença / Proteínas Ricas em Prolina do Estrato Córneo Tipo de estudo: Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Investig Allergol Clin Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Alemanha