Evidence of prophylaxis treatment in adult haemophiliacs. Need of this treatment strategy?
Hamostaseologie
; 31 Suppl 1: S34-7, 2011 Nov.
Article
em En
| MEDLINE
| ID: mdl-22057946
ABSTRACT
In contrast to children with haemophilia the scientific evidence of prophylaxis treatment in adults is not yet proven. Existing studies are of observational character and mostly retrospectively designed. Therefore, opinion leaders in this field postulate prospectively designed, randomized, controlled and multicentric studies to set up urgently needed guidelines. Evidence according to the Canadian task force ranking is assessed as level III with a recommendation grade C by the authors. The recognition of benefits of health care providers in accordance with the German Federal Joint Committee generally demands a Grade-Ia to Ib evidence. As long as the actual evidence of prophylaxis in adult haemophiliacs does not meet the postulated criteria of the German Federal Joint Committee, prophylactic replacement therapy of the individual case has to be well documented and reasonably explained.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Qualidade de Vida
/
Atividades Cotidianas
/
Medicina Baseada em Evidências
/
Hemofilia A
/
Artropatias
Tipo de estudo:
Clinical_trials
/
Guideline
/
Prevalence_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Hamostaseologie
Ano de publicação:
2011
Tipo de documento:
Article