Marked nitrosation by stimulation with lipopolysaccharide in ascorbic acid-deficient rats.
Carcinogenesis
; 11(10): 1887-9, 1990 Oct.
Article
em En
| MEDLINE
| ID: mdl-2208602
ABSTRACT
Marked formation of N-nitrosothioproline (N-nitrosothiazolidine-4-carboxylic acid) by stimulation with Escherichia coli lipopolysaccharide (LPS) was demonstrated in ascorbic acid-deficient mutant rats (osteogenic disorder syndrome rats; ODS rats) unable to synthesize ascorbic acid. The amounts of urinary nitrate and N-nitrosothioproline excretion after thioproline administration was measured in ODS rats with and without ascorbic acid supplement before and after the injection of LPS. LPS caused marked increase of urinary nitrate excretion in both groups. Urinary N-nitrosothioproline excretion increased 6-fold after LPS injection in ODS rats not supplied with ascorbic acid, but supplement with ascorbic acid markedly decreased the excretion of N-nitrosothioproline.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Ascórbico
/
Deficiência de Ácido Ascórbico
/
Tiazóis
/
Lipopolissacarídeos
/
Nitratos
/
Compostos Nitrosos
Limite:
Animals
Idioma:
En
Revista:
Carcinogenesis
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Japão