Sudden death after exercise in an adolescent with hemoglobin SE.
Am J Forensic Med Pathol
; 32(4): 341-3, 2011 Dec.
Article
em En
| MEDLINE
| ID: mdl-22101436
ABSTRACT
Hemoglobin (Hb) S and Hb E are the most common variant hemoglobins, but because of the geographical separation of the areas where they are prevalent, the combination of the 2 is uncommon. Approximately 46 cases of hemoglobin SE compound heterozygosity have been reported. No deaths from the condition have been reported previously, whereas death after vigorous physical activity in individuals with sickle cell trait (hemoglobin AS) has been described in a few case reports. Here we report previously undiagnosed hemoglobinopathy SE in a 12-year-old American boy who collapsed during football practice and had a cardiac arrest on the field after a brief lucid interval. The autopsy was significant only for postmortem intravascular sickling. A postmortem hemoglobin electrophoresis test revealed 57% S, 34% E, and 1% F hemoglobins. The death is attributed to cardiac ischemia from functional vaso-occlusion by sickled erythrocytes.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hemoglobina E
/
Hemoglobina Falciforme
/
Morte Súbita
/
Parada Cardíaca
/
Hemoglobinopatias
Limite:
Child
/
Humans
/
Male
Idioma:
En
Revista:
Am J Forensic Med Pathol
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos