YS-822A, a new polyene macrolide antibiotic. I. Production, isolation, characterization and biological properties.
J Antibiot (Tokyo)
; 43(8): 948-55, 1990 Aug.
Article
em En
| MEDLINE
| ID: mdl-2211361
ABSTRACT
A new polyene macrolide antibiotic, YS-822A was isolated from the culture filtrate of a mutant strain H-8 of Streptoverticillium eurocidicum var. asterocidicus S-822. Whereas the original S-822 strain produced not only YS-822 substances but also teleocidin as by-product which is well-known as a strong carcinogenic promoter, the mutagenized H-8 strain produced the antibiotic with only a trace amount of teleocidin. Chemical and biological characterizations of the antibiotic revealed that YS-822A (molecular formula C37H59NO14) is a new polyene macrolide with a wide antifungal spectrum and a low acute toxicity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Streptomycetaceae
/
Macrolídeos
/
Fungos
/
Antibacterianos
/
Antifúngicos
Limite:
Animals
Idioma:
En
Revista:
J Antibiot (Tokyo)
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Japão