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Osteopontin is critical to determine symptom severity of influenza through the regulation of NK cell population.
Sato, Kayoko; Iwai, Atsushi; Nakayama, Yosuke; Morimoto, Junko; Takada, Ayato; Maruyama, Mitsuo; Kida, Hiroshi; Uede, Toshimitsu; Miyazaki, Tadaaki.
Afiliação
  • Sato K; Department of Bioresources, Hokkaido University Research Center for Zoonosis Control, Kita-ku, Sapporo, Hokkaido, Japan.
Biochem Biophys Res Commun ; 417(1): 274-9, 2012 Jan 06.
Article em En | MEDLINE | ID: mdl-22155230
ABSTRACT
Osteopontin (OPN) is involved in exacerbating various inflammatory diseases. A severe pulmonary inflammation is frequently found in lethal influenza A virus (IAV) infection. However, the function of OPN against the infection was poorly understood. Here, we demonstrate an importance of OPN on immune response and disease severity after IAV infection. We found that the expression level of OPN was increased in mice infected with IAV. The OPN knockout (KO) mice exhibited a severe pathological phenotype and the survival rate decreased after the lethal IAV infection, compared to the wild type mice, while the survival rate increased in OPN transgenic (Tg) mice. The population of natural killer (NK) cells significantly decreased in OPN KO mice at day 5 after the infection, whereas, it increased in OPN Tg mice. These results suggest that OPN plays an important role in host defense against IAV infection through the regulation of NK cell population.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Influenza A / Pneumonia Viral / Células Matadoras Naturais / Infecções por Orthomyxoviridae / Osteopontina Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Japão

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Influenza A / Pneumonia Viral / Células Matadoras Naturais / Infecções por Orthomyxoviridae / Osteopontina Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Japão