Structural studies of the hypothalamus and its nuclei in mood disorders.
Psychiatry Res
; 201(1): 1-9, 2012 Jan 30.
Article
em En
| MEDLINE
| ID: mdl-22285717
ABSTRACT
A large body of evidence indicates that the hypothalamus is involved in pathogenetic mechanisms of mood disorders. It has been suggested that functional abnormalities of the hypothalamus are associated with structural hypothalamic changes. Structural neuroimaging allows in vivo investigation of the hypothalamus that may shed light on the underlying pathogenetic mechanisms of unipolar and bipolar disorder. Clearly, the detection of subtle structural cerebral changes depends on the limitations of the neuroimaging technique used. Making a comprehensive database search, we reviewed the literature on hypothalamic macrostructure in affective disorders, addressing the specific question of what structural magnetic resonance imaging might be expected to show. Studies with convincing methodology, although rare, suggest a global volume decrease in the hypothalamus in affective disorders, a decrease which is not shown by the two specific nuclei investigated, the paraventricular and supraoptic nuclei. We discuss the implications of these findings and provide directions for future research.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos do Humor
/
Hipotálamo
/
Neurônios
Limite:
Humans
Idioma:
En
Revista:
Psychiatry Res
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Alemanha