Montelukast as a treatment modality for eosinophilic gastroenteritis.
Acta Gastroenterol Belg
; 74(4): 570-5, 2011 Dec.
Article
em En
| MEDLINE
| ID: mdl-22319970
ABSTRACT
Eosinophilic Gastroenteritis (EG) is a rare condition, caused by eosinophilic inflammatory infiltrates in the gastrointestinal tract. It is usually treated successfully with systemic glucocorticoids. Because of frequent relapses, however, there is need for alternatives. We describe a 38-year old man with steroid-dependent EG, who was successfully treated with montelukast, a leukotriene receptor antagonist. It inhibits leukotriene D4, an important cytokine in the inflammatory cascade. Although montelukast could not replace steroid therapy, it acted as a steroid sparing agent in our patient. Review of the literature shows that montelukast is efficient in the treatment of EG in a part of the patients. The low cost, the low number of side effects and its efficiency make it an interesting alternative in relapsing or steroid dependent EG. There is need for multicentric studies regarding the treatment of EG.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Quinolinas
/
Antagonistas de Leucotrienos
/
Eosinofilia
/
Gastroenterite
/
Acetatos
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Acta Gastroenterol Belg
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Bélgica