The influence of genes mapping within the major histocompatibility complex on resistance to Trichuris muris infections in mice.
Parasitology
; 101 Pt 1: 61-7, 1990 Aug.
Article
em En
| MEDLINE
| ID: mdl-2235076
ABSTRACT
Two panels of H-2 recombinant strains of mice were used in an attempt to map the H-2-linked genes which control resistance to infection with Trichuris muris. Response phenotypes could be related to the presence of 'resistance' (q,b) or 'susceptibility' (k,d) alleles at I-A. The influence of these genes was modulated by other alleles, particularly q or d alleles, at the D end of the H-2. Absence of I-E molecules correlated with resistance to infection in some but not all strains studied. Thus the (B10.BR x B10.G) F1 strain which expressed I-Ek gene products was resistant to infection. A study of the time-course of infection in strains of mice expressing q alleles throughout the H-2 on 4 different genetic backgrounds (NIH, SWR, DBA and B10) revealed that most strains were resistant to infection. However, the DBA/1 strain exhibited differential responsiveness, 4 out of 6 individuals harbouring mature adult parasites on day 35 post-infection.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tricuríase
/
Genes MHC Classe I
/
Alelos
/
Complexo Principal de Histocompatibilidade
Limite:
Animals
Idioma:
En
Revista:
Parasitology
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Reino Unido