Functional interactions between B lymphocytes and the innate immune system.
Infect Disord Drug Targets
; 12(3): 191-9, 2012 Jun.
Article
em En
| MEDLINE
| ID: mdl-22394177
ABSTRACT
The immune system is composed of multiple cell types, which together improve the resistance of the organism against infections. The unfolding of a successful host response ensuring effective protection against pathogens requires an appropriate coordination of the different players of the immune system. Innate cells and T cells extensively communicate during immune reactions, providing multiple opportunities for the mutual coordination of these two defense pathways. Little is known about the functional interactions between B and innate cells, and it is generally assumed that they influence each other indirectly through effects on T cells. However, recent studies highlighted important roles for innate cells in initial presentation of antigen to B cells after immunization, and in long-term maintenance of antibody-producing cells in bone marrow after resolution of immune responses. Furthermore, it was found that activated B cells could regulate the activity of innate cells through production of cytokines. Here, we review how direct interactions between innate and B cells can contribute to orchestration of humoral and cellular immunity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Imunidade Humoral
/
Imunidade Celular
/
Imunidade Inata
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Infect Disord Drug Targets
Assunto da revista:
DOENCAS TRANSMISSIVEIS
/
TERAPIA POR MEDICAMENTOS
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Alemanha