Passive smoke exposure of female rats caused aortic atherosclerotic precursor lesions in their offspring.
Fetal Pediatr Pathol
; 31(3): 120-7, 2012 Jun.
Article
em En
| MEDLINE
| ID: mdl-22413908
ABSTRACT
The aim of this study was to evaluate the presence and degree of preclinical atherosclerosis in pups of pregnant rats exposed to cigarette smoke. Abdominal aorta examined for atherosclerotic lesions and intimal medial thickness of the abdominal aorta was measured by image analysis. The study groups showed endothelial cellular losses, marked intimal injuries, elastic fiber damages, mononuclear cellular infiltration, and irregularities in internal elastic membrane, with pronounced damages as integrity losses and local fragmentations. The results provide evidence for development of an atherosclerotic process in the neonatal period, even in prenatal stage, long before the formation of smoke-related cardiovascular diseases.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aorta Abdominal
/
Efeitos Tardios da Exposição Pré-Natal
/
Poluição por Fumaça de Tabaco
/
Doença da Artéria Coronariana
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Fetal Pediatr Pathol
Assunto da revista:
PATOLOGIA
/
PEDIATRIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Turquia