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Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling.
Fonseca, Bruno D; Diering, Graham H; Bidinosti, Michael A; Dalal, Kush; Alain, Tommy; Balgi, Aruna D; Forestieri, Roberto; Nodwell, Matt; Rajadurai, Charles V; Gunaratnam, Cynthia; Tee, Andrew R; Duong, Franck; Andersen, Raymond J; Orlowski, John; Numata, Masayuki; Sonenberg, Nahum; Roberge, Michel.
Afiliação
  • Fonseca BD; Department of Biochemistry and Molecular Biology, 2350 Health Sciences Mall, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada; Department of Biochemistry, 1160 Pine Avenue West, Rosalind and Morris Goodman Cancer Centre, McGill University, Montreal
  • Diering GH; Department of Biochemistry and Molecular Biology, 2350 Health Sciences Mall, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
  • Bidinosti MA; Department of Biochemistry, 1160 Pine Avenue West, Rosalind and Morris Goodman Cancer Centre, McGill University, Montreal, Quebec H3A 1A3, Canada.
  • Dalal K; Department of Biochemistry and Molecular Biology, 2350 Health Sciences Mall, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
  • Alain T; Department of Biochemistry, 1160 Pine Avenue West, Rosalind and Morris Goodman Cancer Centre, McGill University, Montreal, Quebec H3A 1A3, Canada.
  • Balgi AD; Department of Biochemistry and Molecular Biology, 2350 Health Sciences Mall, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
  • Forestieri R; Departments of Chemistry and Earth and Ocean Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada.
  • Nodwell M; Departments of Chemistry and Earth and Ocean Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada.
  • Rajadurai CV; Department of Biochemistry, 1160 Pine Avenue West, Rosalind and Morris Goodman Cancer Centre, McGill University, Montreal, Quebec H3A 1A3, Canada.
  • Gunaratnam C; Department of Biochemistry and Molecular Biology, 2350 Health Sciences Mall, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
  • Tee AR; Institute of Medical Genetics, Wales College of Medicine, Cardiff University, Heath Park Way, Cardiff CF14 4XN, United Kingdom.
  • Duong F; Department of Biochemistry and Molecular Biology, 2350 Health Sciences Mall, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
  • Andersen RJ; Departments of Chemistry and Earth and Ocean Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada.
  • Orlowski J; Department of Physiology, 3655 Promenade Sir William Osler, Bellini Building, McGill University, Montreal, Quebec H3G 1Y6, Canada.
  • Numata M; Department of Biochemistry and Molecular Biology, 2350 Health Sciences Mall, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
  • Sonenberg N; Department of Biochemistry, 1160 Pine Avenue West, Rosalind and Morris Goodman Cancer Centre, McGill University, Montreal, Quebec H3A 1A3, Canada.
  • Roberge M; Department of Biochemistry and Molecular Biology, 2350 Health Sciences Mall, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. Electronic address: michelr@mail.ubc.ca.
J Biol Chem ; 287(21): 17530-17545, 2012 May 18.
Article em En | MEDLINE | ID: mdl-22474287
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Proteínas / Niclosamida / Antinematódeos Limite: Animals / Female / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2012 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Proteínas / Niclosamida / Antinematódeos Limite: Animals / Female / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2012 Tipo de documento: Article