Kim-1/Tim-1 and immune cells: shifting sands.
Kidney Int
; 81(9): 809-11, 2012 May.
Article
em En
| MEDLINE
| ID: mdl-22499138
ABSTRACT
Kim-1/Tim-1 is an apoptotic-cell phagocytosis and scavenger receptor that is most highly upregulated in proximal tubular epithelium in acute and chronic kidney injury. While Kim-1/Tim-1 has been proposed to be a costimulatory molecule for immune cells, its potential immunological role has been controversial. In the presence of very high epithelial cell expression, understanding the influence of immune cell Kim-1/Tim-1 expression in kidney injury relies on a better definition of its functional significance in immune cells and better characterization of antibodies used to probe function.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ativação Linfocitária
/
Linfócitos T CD4-Positivos
/
Glomerulonefrite
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Imunidade Celular
/
Rim
/
Proteínas de Membrana
Limite:
Animals
Idioma:
En
Revista:
Kidney Int
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos