Synthesis, characterization, and antimicrobial activity of nano-hydroxyapatite-zinc for bone tissue engineering applications.
J Nanosci Nanotechnol
; 12(1): 167-72, 2012 Jan.
Article
em En
| MEDLINE
| ID: mdl-22523961
ABSTRACT
The bone implants used in tissue repair are susceptible to infections caused by staphylococci, specifically Staphylococcus aureus. Hence, the development of better biological materials that provide antimicrobial activity in bone tissue engineering is required. The nanoparticles of hydroxyapatite (nHAp) and nHAp dopped with Zn (nHAp-Zn) were prepared by the wet chemical method and the ion exchange method, respectively. They were characterized using SEM, AFM, FTIR and XRD. The antibacterial activity of nHAp and nHAp-Zn was determined with Gram-negative and Gram-positive bacterial strains. The results indicated that nHAp alone was acting as an inert matrix and when substituted with Zn, it showed better antibacterial activity. The nHAp-Zn was found to be non-toxic to osteoprogenitor cells. Thus, due to the antimicrobial property of nHAp-Zn nanoparticles, we suggest that they would have potential applications towards bone tissue engineering.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteoblastos
/
Zinco
/
Durapatita
/
Substitutos Ósseos
/
Fenômenos Fisiológicos Bacterianos
/
Nanoestruturas
Limite:
Animals
Idioma:
En
Revista:
J Nanosci Nanotechnol
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Índia