PDEI-5 for erectile dysfunction: a potential role in seizure susceptibility.
J Sex Med
; 9(8): 2111-21, 2012 Aug.
Article
em En
| MEDLINE
| ID: mdl-22613050
ABSTRACT
INTRODUCTION:
There is a high prevalence of erectile dysfunction (ED) in men with epilepsy; however, few studies have been conducted concerning the treatment of ED in this neurological group.AIM:
The main purpose of this review is to highlight the influence of phosphodiesterase type 5 inhibitor (PDEI-5) for ED on seizure susceptibility.METHODS:
All available online articles with information pertaining to PDEI-5 and seizure susceptibility were included in this review. MAIN OUTCOMEMEASURES:
The main outcome assessed demonstrated the intriguing role of PDEI-5 and its metabolites on seizure susceptibility.RESULTS:
Case reports in men without epilepsy described seizure occurrence and electrophysiological changes following sildenafil, tadalafil, or vardenafil treatment. Consistent with these findings, preclinical studies suggested a proconvulsant effect of PDEI-5 on models of seizure induction.CONCLUSIONS:
Evidence suggests an influence of PDEI-5 on seizure susceptibility in humans. In addition, preclinical studies have demonstrated the role of nitric oxide metabolites in the facilitation of paroxysmal phenomenon. Although there are many causes of seizures, medical professionals should be aware of the possible influence of PDEI-5 on seizure susceptibility. Further investigation by physicians and scientists is required to improve our understanding of this important topic.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Convulsões
/
Inibidores da Fosfodiesterase 5
/
Disfunção Erétil
Tipo de estudo:
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Animals
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
J Sex Med
Assunto da revista:
GINECOLOGIA
/
MEDICINA REPRODUTIVA
/
UROLOGIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Brasil