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Depot-specific regulation of autotaxin with obesity in human adipose tissue.
Rancoule, Chloé; Dusaulcy, Rodolphe; Tréguer, Karine; Grès, Sandra; Guigné, Charlotte; Quilliot, Didier; Valet, Philippe; Saulnier-Blache, Jean Sébastien.
Afiliação
  • Rancoule C; Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Inserm U1048, Université Paul Sabatier, Equipe n°3 (Bat L4), 1 Avenue Jean Poulhès, BP 84225, 31432 Toulouse Cedex 4, France.
J Physiol Biochem ; 68(4): 635-44, 2012 Dec.
Article em En | MEDLINE | ID: mdl-22644624
Autotaxin (ATX) is a lysophospholipase D involved in synthesis of a bioactive mediator: lysophosphatidic. ATX is abundantly produced by adipocytes and exerts a negative action on adipose tissue expansion. In both mice and humans, ATX expression increases with obesity in association with insulin resistance. In the present study, fat depot-specific regulation of ATX was explored in human. ATX mRNA expression was quantified in visceral and subcutaneous adipose tissue in obese (BMI > 40 kg/m(2); n = 27) and non-obese patients (BMI < 25 kg/m(2); n = 10). Whatever the weight status of the patients is, ATX expression was always higher (1.3- to 6-fold) in subcutaneous than in visceral fat. Nevertheless, visceral fat ATX was significantly higher (42 %) in obese than in non-obese patients, whereas subcutaneous fat ATX remained unchanged. In obese patients, visceral fat ATX expression was positively correlated with diastolic arterial blood pressure (r = 0.67; P = 0.001). This correlation was not observed with subcutaneous fat ATX. Visceral fat ATX was mainly correlated with leptin (r = 0.60; P = 0.001), inducible nitric oxide synthase (r = 0.58; P = 0,007), and apelin receptor (r = 0.50; P = 0.007). These correlations were not observed with subcutaneous fat ATX. These results reveal that obesity-associated upregulation of human adipose tissue ATX is specific to the visceral fat depot.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diester Fosfórico Hidrolases / Gordura Intra-Abdominal / Gordura Subcutânea / Obesidade Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans Idioma: En Revista: J Physiol Biochem Assunto da revista: BIOQUIMICA / FISIOLOGIA Ano de publicação: 2012 Tipo de documento: Article País de afiliação: França

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diester Fosfórico Hidrolases / Gordura Intra-Abdominal / Gordura Subcutânea / Obesidade Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans Idioma: En Revista: J Physiol Biochem Assunto da revista: BIOQUIMICA / FISIOLOGIA Ano de publicação: 2012 Tipo de documento: Article País de afiliação: França